N-Acetylcysteine Improves Renal Function and Reduces Tissue Malondialdehyde Levels in Glycerol-Induced Acute Kidney Injury

Introduction: The etiology of myoglobinuric acute kidney injury involves oxidative brought on by the Fenton reaction and myoglobin redox cycle. Renal tubules may be harmed, lipid peroxidation compounds with vasoconstrictor characteristics produced. N-acetylcysteine (NAC) is an antioxidant shown to improve renal microcirculation have protective effects in various models damage. aim study was demonstrate impact NAC glycerol-induced rats measuring tissue malondialdehyde (MDA) level function test (RFT), determine correlation between effect dose.Methods: This measured examine any a rat model whether dose-related. Five groups male Wistar were used: 1) saline control group, (2) glycerol (50%, 8mL/kg, i.m) plus i.v 3) (100 mg/kg)-treated 4) (200 5) (400 group. At 24 hrs, after injection, sacrificed, cardiac blood taken for measurement, tissues removed thiobarbituric acid MDA assessment.Results: Our revealed that administration significantly amplified MDA, serum creatinine, BUN (blood urea nitrogen) levels. However, dampened increment deterioration (p<0.05). Moreover, BUN, creatinine levels correlated dose (r=0.485; r=0.491; rs=0.544, respectively; all p<0.05), indicating protection declines increments.Conclusion: In this model, intravenous 100 mg/kg reduced improved function. Nevertheless, diminished higher doses.